| 1. Ronde | 23.07.2021 | FK Lviv | - | FK Mariupol | 1:1 |  |
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| 2. Ronde | 01.08.2021 | FK Mariupol | - | Desna Chernigov | 1:2 | |
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| 3. Ronde | 07.08.2021 | SK Dnipro-1 | - | FK Mariupol | 2:1 | ||||
| 4. Ronde | 16.08.2021 | FK Mariupol | - | Chernomorets Odessa | 2:3 | |
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| 5. Ronde | 22.08.2021 | FK Mariupol | - | Zorya Lugansk | 3:4 | |
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| 6. Ronde | 28.08.2021 | Inhulets Petrove | - | FK Mariupol | 3:0 | ||||
| 7. Ronde | 12.09.2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 | |
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| 9. Ronde | 25.09.2021 | FK Oleksandriya | - | FK Mariupol | 2:1 | ||||
| 10. Ronde | 01.10.2021 | FK Mariupol | - | Rukh Lviv | 0:2 | ||||
| 11. Ronde | 16.10.2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | |
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| 12. Ronde | 23.10.2021 | NK Veres | - | FK Mariupol | 2:0 |
Oekraïne