| 5. Ronde | 05.02.2022 | Mazatlán FC [] | - | UANL Tigres [] | 1:2 | ||||
| 6. Ronde | 12.02.2022 | UANL Tigres [] | - | CF Monterrey [] | 1:0 | ||||
| 8. Ronde | 26.02.2022 | UANL Tigres [] | - | Deportivo Guadalajara [] | 1:3 | ||||
| 10. Ronde | 12.03.2022 | UANL Tigres [] | - | Club León [] | 1:1 | ||||
| 11. Ronde | 19.03.2022 | UANL Tigres [] | - | Mazatlán FC [] | 5:0 | ||||
| 13. Ronde | 02.04.2022 | UANL Tigres [] | - | Atlético San Luis [] | 2:0 | ||||
| 17. Ronde | 30.04.2022 | UANL Tigres [] | - | Atlas Guadalajara [] | 1:1 |
Mexico