| 1. Ronde | 18.09.2021 | Club Necaxa [] | - | Santos Laguna [] | 4:0 | ||||
| 3. Ronde | 02.10.2021 | Atlético San Luis [] | - | Santos Laguna [] | 1:1 | ||||
| 4. Ronde | 09.10.2021 | Mazatlán FC [] | - | Santos Laguna [] | 0:2 | ||||
| 5. Ronde | 16.10.2021 | Santos Laguna [] | - | CF Monterrey [] | 4:1 | ||||
| 7. Ronde | 30.10.2021 | Santos Laguna [] | - | Club Necaxa [] | 0:2 | ||||
| 8. Ronde | 05.11.2021 | UANL Tigres [] | - | Santos Laguna [] | 3:1 | ||||
| 9. Ronde | 13.11.2021 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:2 | ||||
| 10. Ronde | 20.11.2021 | Club León [] | - | Santos Laguna [] | 4:2 |
Mexico