| 3. Ronde | 22.01.2022 | Atlas Guadalajara [] | - | CF Monterrey [] | 2:1 | ||||
| 7. Ronde | 19.02.2022 | Atlas Guadalajara [] | - | UANL Tigres [] | 5:2 |  |
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| 9. Ronde | 05.03.2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 2:2 | ||||
| 11. Ronde | 19.03.2022 | CF Monterrey [] | - | Atlas Guadalajara [] | 1:1 | ||||
| 14. Ronde | 06.04.2022 | Club León [] | - | Atlas Guadalajara [] | 1:0 | ||||
| 15. Ronde | 16.04.2022 | Atlas Guadalajara [] | - | Mazatlán FC [] | 5:1 | ||||
| 16. Ronde | 23.04.2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 17. Ronde | 30.04.2022 | UANL Tigres [] | - | Atlas Guadalajara [] | 1:1 | ||||
| 18. Ronde | 07.05.2022 | Atlas Guadalajara [] | - | Atlético San Luis [] | 2:2 |
Mexico