| 1. Ronde | 08.08.2021 | Stade Rennais | - | RC Lens | 1:1 | ||||
| 2. Ronde | 15.08.2021 | RC Lens | - | AS Saint-Étienne | 2:2 | ||||
| 4. Ronde | 29.08.2021 | RC Lens | - | FC Lorient | 2:2 | ||||
| 10. Ronde | 17.10.2021 | Montpellier HSC | - | RC Lens | 1:0 |  |
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| 11. Ronde | 24.10.2021 | RC Lens | - | FC Metz | 4:1 | ||||
| 12. Ronde | 30.10.2021 | Olympique Lyonnais | - | RC Lens | 2:1 | ||||
| 14. Ronde | 21.11.2021 | Stade Brestois 29 | - | RC Lens | 4:0 | ||||
| 15. Ronde | 26.11.2021 | RC Lens | - | Angers SCO | 2:2 | ||||
| 16. Ronde | 01.12.2021 | Clermont Foot 63 | - | RC Lens | 2:2 | |
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| 18. Ronde | 10.12.2021 | FC Nantes | - | RC Lens | 3:2 | ||||
| 19. Ronde | 22.12.2021 | OGC Nice | - | RC Lens | 2:1 | ||||
| 20. Ronde | 08.01.2022 | RC Lens | - | Stade Rennais | 1:0 | ||||
| 21. Ronde | 15.01.2022 | AS Saint-Étienne | - | RC Lens | 1:2 | ||||
| 22. Ronde | 22.01.2022 | RC Lens | - | Olympique Marseille | 0:2 | ||||
| 34. Ronde | 23.04.2022 | Paris Saint-Germain | - | RC Lens | 1:1 |  |
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| 36. Ronde | 08.05.2022 | Stade de Reims | - | RC Lens | 1:2 | ||||
| 38. Ronde | 21.05.2022 | RC Lens | - | AS Monaco | 2:2 |
Frankrijk