| 1. Ronde | 24.01.2016 | River Plate | - | Cerro Porteño | 0:2 | ||||
| 2. Ronde | 29.01.2016 | Sol de América | - | River Plate | 0:1 | ||||
| 3. Ronde | 04.02.2016 | River Plate | - | Sportivo Luqueño | 0:1 | ||||
| 4. Ronde | 09.02.2016 | Libertad | - | River Plate | 3:1 |  |
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| 7. Ronde | 27.02.2016 | River Plate | - | Guaraní | 1:1 | ||||
| 8. Ronde | 02.03.2016 | Deportivo Capiatá | - | River Plate | 1:1 | ||||
| 9. Ronde | 05.03.2016 | River Plate | - | Club Rubio Ñu | 1:4 | ||||
| 12. Ronde | 01.04.2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 13. Ronde | 06.04.2016 | River Plate | - | Sol de América | 1:1 | ||||
| 14. Ronde | 11.04.2016 | Sportivo Luqueño | - | River Plate | 2:0 |  |
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| 15. Ronde | 17.04.2016 | River Plate | - | Libertad | 1:3 | ||||
| 16. Ronde | 21.04.2016 | General Caballero ZC | - | River Plate | 2:3 | ||||
| 17. Ronde | 25.04.2016 | River Plate | - | Club Nacional | 1:3 | ||||
| 18. Ronde | 01.05.2016 | Guaraní | - | River Plate | 4:2 | ||||
| 19. Ronde | 06.05.2016 | River Plate | - | Deportivo Capiatá | 1:1 | ||||
| 20. Ronde | 08.05.2016 | Club Rubio Ñu | - | River Plate | 1:2 | |
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| 21. Ronde | 14.05.2016 | River Plate | - | General Díaz | 1:1 | ||||
| 22. Ronde | 22.05.2016 | Club Olimpia | - | River Plate | 3:0 |
Paraguay