| 2. Ronde | 15.01.2022 | Club León [] | - | UANL Tigres [] | 1:3 |  |
|||
| 3. Ronde | 22.01.2022 | Deportivo Guadalajara [] | - | Club León [] | 4:0 | ||||
| 9. Ronde | 05.03.2022 | Club León [] | - | Mazatlán FC [] | 1:1 | ||||
| 10. Ronde | 12.03.2022 | UANL Tigres [] | - | Club León [] | 1:1 | ||||
| 12. Ronde | 26.03.2022 | Club León [] | - | Deportivo Guadalajara [] | 1:4 | ||||
| 13. Ronde | 02.04.2022 | Mazatlán FC [] | - | Club León [] | 0:3 | ||||
| 16. Ronde | 23.04.2022 | Club León [] | - | Club Tijuana [] | 2:1 | ||||
| 17. Ronde | 30.04.2022 | Club León [] | - | CF Monterrey [] | 1:1 | ||||
| 15. Ronde | 03.05.2022 | Atlético San Luis [] | - | Club León [] | 0:3 | ||||
| 18. Ronde | 07.05.2022 | Santos Laguna [] | - | Club León [] | 2:3 |
Mexico