| 24. Ronde | 23.01.2022 | SD Huesca | - | SD Ponferradina | 1:2 | ||||
| 25. Ronde | 29.01.2022 | SD Eibar | - | SD Huesca | 2:1 |  |
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| 26. Ronde | 06.02.2022 | SD Huesca | - | CD Mirandés | 4:0 | ||||
| 27. Ronde | 13.02.2022 | Real Oviedo | - | SD Huesca | 3:3 | ||||
| 28. Ronde | 20.02.2022 | SD Huesca | - | CD Lugo | 1:0 | |
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| 29. Ronde | 26.02.2022 | UD Ibiza | - | SD Huesca | 2:1 | ||||
| 30. Ronde | 05.03.2022 | SD Huesca | - | UD Las Palmas | 0:0 | |
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| 31. Ronde | 13.03.2022 | AD Alcorcón | - | SD Huesca | 1:0 | |
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| 32. Ronde | 18.03.2022 | SD Huesca | - | Burgos CF | 1:0 | ||||
| 33. Ronde | 27.03.2022 | Málaga CF | - | SD Huesca | 0:2 | ||||
| 34. Ronde | 03.04.2022 | SD Huesca | - | UD Almería | 1:1 | |
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| 36. Ronde | 17.04.2022 | SD Huesca | - | Real Zaragoza | 1:1 | ||||
| 37. Ronde | 22.04.2022 | CD Tenerife | - | SD Huesca | 0:0 | ||||
| 38. Ronde | 02.05.2022 | CD Leganés | - | SD Huesca | 2:1 | ||||
| 39. Ronde | 07.05.2022 | SD Huesca | - | Sporting Gijón | 1:1 | ||||
| 40. Ronde | 14.05.2022 | SD Amorebieta | - | SD Huesca | 1:0 | |
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| 41. Ronde | 21.05.2022 | SD Huesca | - | Real Sociedad B | 3:2 |
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