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| 21.01.2022 | 21:00 | CD Tenerife | - | Real Oviedo | 4:0 (2:0) | |
| 22.01.2022 | 16:00 | Real Zaragoza | - | Real Valladolid | 0:0 (0:0) | |
| 18:15 | CF Fuenlabrada | - | UD Las Palmas | 3:2 (1:1) | ||
| 21:00 | Málaga CF | - | UD Ibiza | 0:5 (0:1) | ||
| 23.01.2022 | 14:00 | Burgos CF | - | CD Leganés | 4:0 (3:0) | |
| 16:00 | Sporting Gijón | - | SD Amorebieta | 2:1 (0:1) | ||
| 18:15 | Girona FC | - | CD Lugo | 1:1 (0:0) | ||
| 18:15 | SD Huesca | - | SD Ponferradina | 1:2 (0:1) | ||
| 21:00 | AD Alcorcón | - | CD Mirandés | 0:0 (0:0) | ||
| 24.01.2022 | 21:00 | Real Sociedad B | - | FC Cartagena | 1:2 (0:0) | |
| 21:00 | UD Almería | - | SD Eibar | 0:2 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 24 | 14 | 4 | 6 | 39:19 | 20 | 46 |
| 2 |
|
SD Eibar | 24 | 13 | 7 | 4 | 37:27 | 10 | 46 |
| 3 |
|
Real Valladolid | 24 | 13 | 5 | 6 | 35:24 | 11 | 44 |
| 4 |
|
CD Tenerife | 24 | 12 | 6 | 6 | 33:18 | 15 | 42 |
| 5 |
|
SD Ponferradina | 24 | 11 | 8 | 5 | 30:21 | 9 | 41 |
| 6 |
|
Girona FC | 24 | 11 | 5 | 8 | 33:27 | 6 | 38 |
| 7 |
|
FC Cartagena | 24 | 11 | 3 | 10 | 30:32 | -2 | 36 |
| 8 |
|
UD Las Palmas | 24 | 9 | 8 | 7 | 32:30 | 2 | 35 |
| 9 |
|
UD Ibiza | 24 | 8 | 10 | 6 | 32:26 | 6 | 34 |
| 10 |
|
Real Oviedo | 24 | 7 | 12 | 5 | 26:24 | 2 | 33 |
| 11 |
|
Sporting Gijón | 24 | 8 | 8 | 8 | 26:28 | -2 | 32 |
| 12 |
|
Burgos CF | 24 | 9 | 5 | 10 | 27:24 | 3 | 32 |
| 13 |
|
CD Lugo | 24 | 6 | 13 | 5 | 30:28 | 2 | 31 |
| 14 |
|
Málaga CF | 24 | 8 | 7 | 9 | 23:35 | -12 | 31 |
| 15 |
|
SD Huesca | 24 | 7 | 9 | 8 | 26:23 | 3 | 30 |
| 16 |
|
Real Zaragoza | 24 | 5 | 13 | 6 | 17:23 | -6 | 28 |
| 17 |
|
CD Mirandés | 24 | 7 | 6 | 11 | 31:36 | -5 | 27 |
| 18 |
|
CD Leganés | 24 | 6 | 8 | 10 | 25:30 | -5 | 26 |
| 19 |
|
CF Fuenlabrada | 24 | 4 | 11 | 9 | 20:28 | -8 | 23 |
| 20 |
|
SD Amorebieta | 24 | 3 | 12 | 9 | 28:36 | -8 | 21 |
| 21 |
|
Real Sociedad B | 24 | 4 | 6 | 14 | 20:33 | -13 | 18 |
| 22 |
|
AD Alcorcón | 24 | 2 | 6 | 16 | 18:46 | -28 | 12 |
| Promotie | |
| Play-offs | |
| Degradatie |
