| 1. Ronde | 18.09.2021 | Club Tijuana [] | - | Pumas UNAM [] | 1:2 | ||||
| 4. Ronde | 09.10.2021 | Pumas UNAM [] | - | CF Pachuca [] | 1:1 | ||||
| 3. Ronde | 20.10.2021 | CF América [] | - | Pumas UNAM [] | 3:2 | ||||
| 7. Ronde | 30.10.2021 | Pumas UNAM [] | - | Cruz Azul [] | 2:2 | ||||
| 9. Ronde | 13.11.2021 | Pumas UNAM [] | - | Club Tijuana [] | 2:1 | ||||
| 10. Ronde | 20.11.2021 | Puebla FC [] | - | Pumas UNAM [] | 2:4 |
Mexico