| 3. Ronde | 09.07.2022 | Pumas UNAM [] | - | Deportivo Toluca [] | 3:3 |  |
|||
| 4. Ronde | 16.07.2022 | Deportivo Toluca [] | - | CF Pachuca [] | 0:0 | ||||
| 5. Ronde | 23.07.2022 | FC Juárez [] | - | Deportivo Toluca [] | 2:3 | |
|||
| 6. Ronde | 30.07.2022 | Deportivo Toluca [] | - | CF América [] | 2:1 | ||||
| 7. Ronde | 06.08.2022 | Puebla FC [] | - | Deportivo Toluca [] | 0:3 | |
 |
||
| 8. Ronde | 13.08.2022 | Deportivo Toluca [] | - | Cruz Azul [] | 3:3 | |
|||
| 11. Ronde | 03.09.2022 | Club Necaxa [] | - | Deportivo Toluca [] | 2:0 | ||||
| 12. Ronde | 10.09.2022 | Deportivo Toluca [] | - | Pumas UNAM [] | 1:0 | ||||
| 13. Ronde | 17.09.2022 | CF Pachuca [] | - | Deportivo Toluca [] | 2:0 | |
|||
| 14. Ronde | 24.09.2022 | Deportivo Toluca [] | - | FC Juárez [] | 7:1 | |
|||
| 15. Ronde | 01.10.2022 | CF América [] | - | Deportivo Toluca [] | 2:1 | ||||
| 16. Ronde | 08.10.2022 | Deportivo Toluca [] | - | Puebla FC [] | 3:1 | |
|||
| 17. Ronde | 15.10.2022 | Cruz Azul [] | - | Deportivo Toluca [] | 0:2 | |
|||
| 18. Ronde | 22.10.2022 | Deportivo Toluca [] | - | Gallos Blancos [] | 1:0 | |
Mexico