| 1. Ronde | 09.01.2022 | Pumas UNAM [U20] | - | Deportivo Toluca [U20] | 1:1 |  |
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| 3. Ronde | 23.01.2022 | Pumas UNAM [U20] | - | UANL Tigres [U20] | 2:1 | ||||
| 14. Ronde | 27.01.2022 | Pumas UNAM [U20] | - | CF Monterrey [U20] | 4:0 | |
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| 4. Ronde | 06.02.2022 | Club Tijuana [U20] | - | Pumas UNAM [U20] | 1:1 | ||||
| 5. Ronde | 13.02.2022 | Pumas UNAM [U20] | - | Club León [U20] | 2:1 | |
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| 6. Ronde | 20.02.2022 | Atlas Guadalajara [U20] | - | Pumas UNAM [U20] | 0:0 | ||||
| 7. Ronde | 26.02.2022 | Pumas UNAM [U20] | - | CF América [U20] | 0:1 | ||||
| 8. Ronde | 02.03.2022 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 10. Ronde | 12.03.2022 | Cruz Azul [U20] | - | Pumas UNAM [U20] | 1:0 Toeg. | ||||
| 11. Ronde | 19.03.2022 | Pumas UNAM [U20] | - | Club Necaxa [U20] | 1:2 | ||||
| 9. Ronde | 27.03.2022 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 12. Ronde | 02.04.2022 | FC Juárez [U20] | - | Pumas UNAM [U20] | 3:2 | |
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| 13. Ronde | 08.04.2022 | Puebla FC [U20] | - | Pumas UNAM [U20] | 2:2 | ||||
| 15. Ronde | 20.04.2022 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 2:1 |  |
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| 17. Ronde | 01.05.2022 | Pumas UNAM [U20] | - | CF Pachuca [U20] | 2:1 | |
Mexico