| 5. Ronde | 06.08.2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 8. Ronde | 23.08.2021 | River Plate II | - | Aldosivi II | 3:0 |  |
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| 16. Ronde | 15.10.2021 | River Plate II | - | San Lorenzo II | 1:3 | ||||
| 17. Ronde | 20.10.2021 | Talleres de Córdoba II | - | River Plate II | 1:0 | ||||
| 18. Ronde | 26.10.2021 | River Plate II | - | Argentinos Juniors II | 0:3 | ||||
| 19. Ronde | 31.10.2021 | Estudiantes II | - | River Plate II | 0:0 | ||||
| 20. Ronde | 05.11.2021 | River Plate II | - | Patronato de Paraná II | 2:0 | ||||
| 21. Ronde | 19.11.2021 | Platense II | - | River Plate II | 5:2 | |
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| 22. Ronde | 23.11.2021 | River Plate II | - | Racing Club II | 1:2 | ||||
| 23. Ronde | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 24. Ronde | 03.12.2021 | River Plate II | - | Defensa y Justicia II | 2:1 | |
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| 25. Ronde | 10.12.2021 | Atlético Tucumán II | - | River Plate II | 1:1 | |
Colombia