| 1. Ronde | 04.04.2021 | Cobreloa | - | Barnechea | 1:2 | ||||
| 2. Ronde | 18.04.2021 | San Marcos | - | Cobreloa | 0:0 | ||||
| 3. Ronde | 26.04.2021 | Cobreloa | - | Universidad de Concepción | 2:4 |  |
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| 4. Ronde | 04.05.2021 | Cobreloa | - | Coquimbo Unido | 1:1 | ||||
| 6. Ronde | 18.05.2021 | Cobreloa | - | Santiago Morning | 2:2 | |
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| 8. Ronde | 30.05.2021 | Cobreloa | - | San Luis | 1:0 | |
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| 10. Ronde | 09.07.2021 | Cobreloa | - | Deportes Iquique | 3:2 | ||||
| 11. Ronde | 15.07.2021 | Deportes Copiapó | - | Cobreloa | 0:0 | ||||
| 12. Ronde | 21.07.2021 | Cobreloa | - | Puerto Montt | 2:0 | |
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| 13. Ronde | 31.07.2021 | Deportes Temuco | - | Cobreloa | 1:0 | ||||
| 14. Ronde | 08.08.2021 | Cobreloa | - | Santa Cruz | 0:1 | ||||
| 17. Ronde | 29.08.2021 | Cobreloa | - | San Marcos | 0:3 Toeg. | ||||
| 18. Ronde | 02.09.2021 | Universidad de Concepción | - | Cobreloa | 0:0 | ||||
| 20. Ronde | 16.09.2021 | Cobreloa | - | Unión San Felipe | 2:1 |  |
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| 21. Ronde | 22.09.2021 | Santiago Morning | - | Cobreloa | 2:1 | ||||
| 22. Ronde | 26.09.2021 | Cobreloa | - | Fernández Vial | 1:2 | ||||
| 7. Ronde | 21.10.2021 | Fernández Vial | - | Cobreloa | 3:2 | ||||
| 29. Ronde | 07.11.2021 | Santa Cruz | - | Cobreloa | 2:2 | ||||
| 30. Ronde | 13.11.2021 | Cobreloa | - | Rangers | 4:1 | |
Argentinië