| 2. Ronde | 29.08.2021 | AS Cittadella | - | FC Crotone | 4:2 | ||||
| 3. Ronde | 11.09.2021 | FC Crotone | - | Reggina 1914 | 1:1 | ||||
| 4. Ronde | 17.09.2021 | Brescia Calcio | - | FC Crotone | 2:2 |  |
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| 5. Ronde | 21.09.2021 | FC Crotone | - | US Lecce | 0:3 | ||||
| 7. Ronde | 02.10.2021 | FC Crotone | - | Ascoli Calcio | 2:2 | ||||
| 8. Ronde | 16.10.2021 | FC Crotone | - | Pisa SC | 2:1 | ||||
| 9. Ronde | 22.10.2021 | US Alessandria 1912 | - | FC Crotone | 1:0 | ||||
| 10. Ronde | 28.10.2021 | FC Crotone | - | Benevento Calcio | 0:2 | ||||
| 11. Ronde | 01.11.2021 | Frosinone Calcio | - | FC Crotone | 2:1 | ||||
| 12. Ronde | 07.11.2021 | FC Crotone | - | AC Monza | 1:1 |  |
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| 13. Ronde | 20.11.2021 | AC Perugia Calcio | - | FC Crotone | 2:0 | ||||
| 14. Ronde | 26.11.2021 | FC Crotone | - | L.R. Vicenza | 0:1 | ||||
| 15. Ronde | 29.11.2021 | Ternana Calcio | - | FC Crotone | 1:0 | ||||
| 18. Ronde | 18.12.2021 | FC Crotone | - | Pordenone Calcio | 4:1 |
Ghana