| 1. Ronde | 18.01.2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 2. Ronde | 21.01.2021 | Montevideo Wanderers | - | Danubio | 2:0 |  |
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| 3. Ronde | 31.01.2021 | Nacional | - | Montevideo Wanderers | 2:1 | ||||
| 4. Ronde | 04.02.2021 | Montevideo Wanderers | - | Boston River | 2:2 | ||||
| 5. Ronde | 06.02.2021 | Deportivo Maldonado | - | Montevideo Wanderers | 1:1 |  |
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| 6. Ronde | 10.02.2021 | Montevideo Wanderers | - | Rentistas | 3:2 | |
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| 7. Ronde | 13.02.2021 | Cerro Largo | - | Montevideo Wanderers | 1:3 | |
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| 8. Ronde | 17.02.2021 | Liverpool | - | Montevideo Wanderers | 2:1 | |
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| 9. Ronde | 21.02.2021 | Montevideo Wanderers | - | Peñarol | 0:1 | |
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| 10. Ronde | 27.02.2021 | River Plate | - | Montevideo Wanderers | 1:1 | |
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| 13. Ronde | 21.03.2021 | Montevideo Wanderers | - | Progreso | 3:0 Toeg. | ||||
| 14. Ronde | 25.03.2021 | Fénix | - | Montevideo Wanderers | 3:3 |
Argentinië