| 1. Ronde | 15.05.2021 | Montevideo Wanderers | - | Boston River | 1:0 |  |
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| 3. Ronde | 31.05.2021 | Rentistas | - | Montevideo Wanderers | 0:1 |  |
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| 4. Ronde | 07.06.2021 | Montevideo Wanderers | - | Peñarol | 0:0 | ||||
| 5. Ronde | 11.06.2021 | Montevideo City Torque | - | Montevideo Wanderers | 2:1 | ||||
| 6. Ronde | 19.06.2021 | Montevideo Wanderers | - | Villa Española | 3:0 | ||||
| 8. Ronde | 29.06.2021 | Montevideo Wanderers | - | Cerrito | 1:0 | ||||
| 9. Ronde | 06.07.2021 | Liverpool | - | Montevideo Wanderers | 2:1 | |
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| 10. Ronde | 10.07.2021 | Montevideo Wanderers | - | River Plate | 1:2 | ||||
| 11. Ronde | 17.07.2021 | Cerro Largo | - | Montevideo Wanderers | 2:0 | ||||
| 12. Ronde | 31.07.2021 | Montevideo Wanderers | - | Progreso | 2:0 | |
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| 13. Ronde | 09.08.2021 | Sud América | - | Montevideo Wanderers | 1:0 | ||||
| 14. Ronde | 16.08.2021 | Montevideo Wanderers | - | Plaza Colonia | 0:2 | |
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| 15. Ronde | 20.08.2021 | Fénix | - | Montevideo Wanderers | 2:1 |
Argentinië