| 10. Ronde | 29.10.2021 | Real Madrid Castilla | - | Villarreal CF B | 2:1 | ||||
| 11. Ronde | 07.11.2021 | Villarreal CF B | - | CD Alcoyano | 0:1 | ||||
| 12. Ronde | 13.11.2021 | Linares Deportivo | - | Villarreal CF B | 2:1 | ||||
| 14. Ronde | 27.11.2021 | RB Linense | - | Villarreal CF B | 1:2 |  |
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| 23. Ronde | 13.02.2022 | FC Andorra | - | Villarreal CF B | 0:1 | ||||
| 25. Ronde | 26.02.2022 | Albacete | - | Villarreal CF B | 1:0 | ||||
| 26. Ronde | 05.03.2022 | Villarreal CF B | - | CE Sabadell | 0:3 | ||||
| 32. Ronde | 16.04.2022 | Villarreal CF B | - | Linares Deportivo | 5:0 | |
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| 35. Ronde | 08.05.2022 | Villarreal CF B | - | Real Madrid Castilla | 4:1 | |
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| 38. Ronde | 28.05.2022 | Atlético Sanluqueño CF | - | Villarreal CF B | 2:1 |
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