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| 27.05.2022 | 18:00 | Real Madrid Castilla | - | Real Betis B | 4:0 (3:0) | |
| 28.05.2022 | 18:30 | CE Sabadell | - | Algeciras CF | 0:1 (0:0) | |
| 18:30 | CD Castellón | - | UE Cornellà | 1:3 (1:0) | ||
| 18:30 | CD Alcoyano | - | Gimnàstic de Tarragona | 0:1 (0:1) | ||
| 18:30 | San Fernando CD | - | Atlético Baleares | 0:4 (0:2) | ||
| 18:30 | Atlético Sanluqueño CF | - | Villarreal CF B | 2:1 (2:0) | ||
| 18:30 | Sevilla Atlético | - | Linares Deportivo | 1:4 (0:2) | ||
| 18:30 | RB Linense | - | FC Andorra | 3:1 (2:1) | ||
| 18:30 | UCAM Murcia CF | - | FC Barcelona B | 1:2 (0:1) | ||
| 18:30 | Albacete | - | UE Costa Brava | 1:3 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Andorra | 38 | 21 | 8 | 9 | 61:38 | 23 | 71 |
| 2 |
|
Villarreal CF B | 38 | 20 | 7 | 11 | 65:36 | 29 | 67 |
| 3 |
|
Albacete | 38 | 19 | 10 | 9 | 52:34 | 18 | 67 |
| 4 |
|
Gimnàstic de Tarragona | 38 | 16 | 13 | 9 | 41:30 | 11 | 61 |
| 5 |
|
Linares Deportivo | 38 | 17 | 9 | 12 | 59:47 | 12 | 60 |
| 6 |
|
Atlético Baleares | 38 | 15 | 14 | 9 | 52:35 | 17 | 59 |
| 7 |
|
Algeciras CF | 38 | 16 | 11 | 11 | 50:39 | 11 | 59 |
| 8 |
|
CE Sabadell | 38 | 16 | 10 | 12 | 44:33 | 11 | 58 |
| 9 |
|
FC Barcelona B | 38 | 16 | 9 | 13 | 59:51 | 8 | 57 |
| 10 |
|
Real Madrid Castilla | 38 | 16 | 8 | 14 | 66:47 | 19 | 56 |
| 11 |
|
CD Alcoyano | 38 | 13 | 13 | 12 | 41:40 | 1 | 52 |
| 12 |
|
RB Linense | 38 | 13 | 11 | 14 | 35:44 | -9 | 50 |
| 13 |
|
CD Castellón | 38 | 14 | 8 | 16 | 37:50 | -13 | 50 |
| 14 |
|
UE Cornellà | 38 | 14 | 6 | 18 | 39:48 | -9 | 48 |
| 15 |
|
San Fernando CD | 38 | 13 | 9 | 16 | 49:58 | -9 | 48 |
| 16 |
|
Atlético Sanluqueño CF | 38 | 12 | 10 | 16 | 39:56 | -17 | 46 |
| 17 |
|
Sevilla Atlético | 38 | 13 | 7 | 18 | 36:55 | -19 | 46 |
| 18 |
|
UCAM Murcia CF | 38 | 8 | 11 | 19 | 42:56 | -14 | 35 |
| 19 |
|
UE Costa Brava | 38 | 6 | 15 | 17 | 26:51 | -25 | 33 |
| 20 |
|
Real Betis B | 38 | 6 | 3 | 29 | 23:68 | -45 | 21 |
| Promotie | |
| Play-offs | |
| Degradatie |
