| 1. Ronde | 09.01.2022 | Santos Laguna [U16] | - | CF Monterrey [U16] | 0:0 | ||||
| 3. Ronde | 22.01.2022 | UANL Tigres [U16] | - | Santos Laguna [U16] | 0:2 | ||||
| 4. Ronde | 29.01.2022 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 0:1 | ||||
| 6. Ronde | 12.02.2022 | Santos Laguna [U16] | - | Atlas Guadalajara [U16] | 5:3 | ||||
| 7. Ronde | 18.02.2022 | Club León [U16] | - | Santos Laguna [U16] | 0:0 | ||||
| 8. Ronde | 26.02.2022 | Mazatlán FC [U16] | - | Santos Laguna [U16] | 2:0 | ||||
| 9. Ronde | 05.03.2022 | Santos Laguna [U16] | - | Club Tijuana [U16] | 2:0 |  |
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| 10. Ronde | 12.03.2022 | Atlas Guadalajara [U16] | - | Santos Laguna [U16] | 2:3 | ||||
| 18. Ronde | 07.05.2022 | Santos Laguna [U16] | - | Club León [U16] | 2:1 |
Mexico