| 5. Ronde | 16.10.2021 | CF América [] | - | Club Tijuana [] | 6:0 | ||||
| 6. Ronde | 23.10.2021 | Club Tijuana [] | - | CF Pachuca [] | 4:2 |  |
 |
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| 7. Ronde | 30.10.2021 | Club Tijuana [] | - | Gallos Blancos [] | 3:0 | ||||
| 8. Ronde | 06.11.2021 | FC Juárez [] | - | Club Tijuana [] | 1:1 | ||||
| 9. Ronde | 13.11.2021 | Pumas UNAM [] | - | Club Tijuana [] | 2:1 | |
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| 10. Ronde | 20.11.2021 | Club Tijuana [] | - | Cruz Azul [] | 1:2 | |
Mexico