| 2. Ronde | 25.09.2021 | Cruz Azul [] | - | CF Pachuca [] | 3:6 | ||||
| 3. Ronde | 02.10.2021 | Cruz Azul [] | - | Gallos Blancos [] | 1:0 | ||||
| 4. Ronde | 09.10.2021 | FC Juárez [] | - | Cruz Azul [] | 4:3 |  |
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| 5. Ronde | 16.10.2021 | Deportivo Toluca [] | - | Cruz Azul [] | 3:0 | ||||
| 6. Ronde | 23.10.2021 | Cruz Azul [] | - | CF América [] | 2:2 | |
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| 7. Ronde | 30.10.2021 | Pumas UNAM [] | - | Cruz Azul [] | 2:2 | ||||
| 8. Ronde | 06.11.2021 | Cruz Azul [] | - | Puebla FC [] | 2:2 | ||||
| 10. Ronde | 20.11.2021 | Club Tijuana [] | - | Cruz Azul [] | 1:2 |
Mexico