| 1. Ronde | 25.06.2022 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 1:0 | ||||
| 2. Ronde | 02.07.2022 | Club Tijuana [U16] | - | Santos Laguna [U16] | 1:2 | ||||
| 3. Ronde | 09.07.2022 | Santos Laguna [U16] | - | CF Monterrey [U16] | 3:1 |  |
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| 10. Ronde | 27.08.2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 1:0 |  |
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| 11. Ronde | 03.09.2022 | Santos Laguna [U16] | - | Club León [U16] | 5:1 | |
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| 12. Ronde | 10.09.2022 | UANL Tigres [U16] | - | Santos Laguna [U16] | 2:1 | ||||
| 13. Ronde | 17.09.2022 | Santos Laguna [U16] | - | Atlas Guadalajara [U16] | 1:0 | ||||
| 9. Ronde | 21.09.2022 | Club León [U16] | - | Santos Laguna [U16] | 0:0 | ||||
| 15. Ronde | 01.10.2022 | Mazatlán FC [U16] | - | Santos Laguna [U16] | 0:4 | ||||
| 16. Ronde | 08.10.2022 | Santos Laguna [U16] | - | Atlético San Luis [U16] | 4:0 | |
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| 17. Ronde | 15.10.2022 | CF Monterrey [U16] | - | Santos Laguna [U16] | 1:2 |
Mexico