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| 17.09.2022 | 16:00 | Santos Laguna | - | Atlas Guadalajara | 1:0 (0:0) | |
| 16:00 | Atlético San Luis | - | Club León | 4:2 (2:1) | ||
| 16:00 | Pumas UNAM | - | Club Necaxa | 2:1 (1:0) | ||
| 18:00 | CF Pachuca | - | Deportivo Toluca | 1:2 (0:1) | ||
| 19:30 | Mazatlán FC | - | UANL Tigres | 1:2 (0:0) | ||
| 23:00 | CF América | - | Cruz Azul | 3:2 (2:1) | ||
| 23:00 | CF Monterrey | - | Deportivo Guadalajara | 1:1 (0:1) | ||
| 19.10.2022 | 16:00 | Gallos Blancos | - | FC Juárez | 3:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 11 | 6 | 3 | 2 | 29:13 | 16 | 21 |
| 2 |
|
CF América | 11 | 6 | 3 | 2 | 24:16 | 8 | 21 |
| 3 |
|
Pumas UNAM | 12 | 5 | 3 | 4 | 15:16 | -1 | 18 |
| 4 |
|
Deportivo Toluca | 11 | 5 | 2 | 4 | 28:24 | 4 | 17 |
| 5 |
|
Cruz Azul | 12 | 4 | 4 | 4 | 26:21 | 5 | 16 |
| 6 |
|
Gallos Blancos | 12 | 5 | 1 | 6 | 15:23 | -8 | 16 |
| 7 |
|
FC Juárez | 12 | 3 | 5 | 4 | 18:20 | -2 | 14 |
| 8 |
|
CF Pachuca | 12 | 4 | 1 | 7 | 14:21 | -7 | 13 |
| 9 |
|
Puebla FC | 11 | 2 | 2 | 7 | 15:30 | -15 | 8 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 12 | 8 | 3 | 1 | 23:12 | 11 | 27 |
| 2 |
|
Santos Laguna | 12 | 8 | 1 | 3 | 20:11 | 9 | 25 |
| 3 |
|
CF Monterrey | 11 | 7 | 1 | 3 | 25:11 | 14 | 22 |
| 4 |
|
Mazatlán FC | 12 | 7 | 1 | 4 | 18:16 | 2 | 22 |
| 5 |
|
Atlas Guadalajara | 11 | 4 | 2 | 5 | 13:14 | -1 | 14 |
| 6 |
|
Atlético San Luis | 12 | 4 | 2 | 6 | 21:24 | -3 | 14 |
| 7 |
|
UANL Tigres | 11 | 4 | 0 | 7 | 11:16 | -5 | 12 |
| 8 |
|
Club Tijuana | 11 | 3 | 2 | 6 | 10:17 | -7 | 11 |
| 9 |
|
Club León | 12 | 0 | 2 | 10 | 15:35 | -20 | 2 |
| Play-offs | |
| Play-offs |
