| 1. Ronde | 08.01.2022 | CF Pachuca [] | - | Puebla FC [] | 2:0 | ||||
| 2. Ronde | 15.01.2022 | Cruz Azul [] | - | CF Pachuca [] | 1:4 |  |
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| 4. Ronde | 29.01.2022 | CF Pachuca [] | - | CF América [] | 3:0 | ||||
| 5. Ronde | 05.02.2022 | Pumas UNAM [] | - | CF Pachuca [] | 4:3 | ||||
| 7. Ronde | 19.02.2022 | CF Pachuca [] | - | Gallos Blancos [] | 3:0 |  |
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| 8. Ronde | 26.02.2022 | CF Pachuca [] | - | FC Juárez [] | 4:0 | |
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| 9. Ronde | 05.03.2022 | Deportivo Toluca [] | - | CF Pachuca [] | 2:4 | |
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| 10. Ronde | 12.03.2022 | CF Pachuca [] | - | Cruz Azul [] | 4:2 | ||||
| 11. Ronde | 19.03.2022 | Puebla FC [] | - | CF Pachuca [] | 0:3 | ||||
| 12. Ronde | 26.03.2022 | CF Pachuca [] | - | Pumas UNAM [] | 2:2 | |
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| 13. Ronde | 03.04.2022 | FC Juárez [] | - | CF Pachuca [] | 1:4 | |
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| 14. Ronde | 09.04.2022 | CF Pachuca [] | - | Club Necaxa [] | 0:1 |
Mexico