| 3. Ronde | 28.07.2021 | Godoy Cruz | - | Atlético Tucumán | 1:2 | ||||
| 4. Ronde | 31.07.2021 | Colón de Santa Fe | - | Godoy Cruz | 1:0 | ||||
| 5. Ronde | 08.08.2021 | Godoy Cruz | - | River Plate | 2:1 | ||||
| 6. Ronde | 17.08.2021 | Lanús | - | Godoy Cruz | 3:1 | ||||
| 10. Ronde | 05.09.2021 | Godoy Cruz | - | Gimnasia de La Plata | 4:0 |  |
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| 11. Ronde | 13.09.2021 | Aldosivi | - | Godoy Cruz | 1:4 | ||||
| 12. Ronde | 18.09.2021 | Godoy Cruz | - | Sarmiento de Junín | 1:1 | ||||
| 13. Ronde | 26.09.2021 | Independiente | - | Godoy Cruz | 1:4 | ||||
| 14. Ronde | 02.10.2021 | Godoy Cruz | - | Newell's Old Boys | 2:2 | ||||
| 15. Ronde | 11.10.2021 | Arsenal de Sarandí | - | Godoy Cruz | 0:0 | ||||
| 17. Ronde | 21.10.2021 | Boca Juniors | - | Godoy Cruz | 2:1 | |
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| 18. Ronde | 24.10.2021 | Godoy Cruz | - | Banfield | 2:1 | |
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| 19. Ronde | 31.10.2021 | San Lorenzo | - | Godoy Cruz | 1:0 | ||||
| 21. Ronde | 20.11.2021 | Argentinos Juniors | - | Godoy Cruz | 0:0 | ||||
| 22. Ronde | 24.11.2021 | Godoy Cruz | - | Estudiantes | 1:3 | |
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| 23. Ronde | 27.11.2021 | Patronato de Paraná | - | Godoy Cruz | 0:3 | ||||
| 24. Ronde | 04.12.2021 | Godoy Cruz | - | Platense | 2:2 | ||||
| 25. Ronde | 11.12.2021 | Racing Club | - | Godoy Cruz | 2:1 |
Argentinië