| 5. Ronde | 25.09.2021 | Cultural Leonesa | - | Real Valladolid B | 4:2 | ||||
| 7. Ronde | 09.10.2021 | Extremadura UD | - | Real Valladolid B | 1:0 | ||||
| 10. Ronde | 29.10.2021 | CF Talavera | - | Real Valladolid B | 0:2 | ||||
| 14. Ronde | 26.11.2021 | UD Logroñés | - | Real Valladolid B | 3:2 | ||||
| 16. Ronde | 12.12.2021 | Deportivo La Coruña | - | Real Valladolid B | 3:0 | ||||
| 17. Ronde | 19.12.2021 | Real Valladolid B | - | Zamora CF | 1:3 | ||||
| 20. Ronde | 26.01.2022 | Rayo Majadahonda | - | Real Valladolid B | 3:1 | ||||
| 23. Ronde | 12.02.2022 | Inter de Madrid | - | Real Valladolid B | 2:2 | ||||
| 25. Ronde | 25.02.2022 | Athletic Club B | - | Real Valladolid B | 3:0 | ||||
| 30. Ronde | 02.04.2022 | CD Tudelano | - | Real Valladolid B | 1:2 | ||||
| 31. Ronde | 10.04.2022 | Real Valladolid B | - | SD Logroñés | 2:0 | ||||
| 32. Ronde | 16.04.2022 | CD Calahorra | - | Real Valladolid B | 2:1 | ||||
| 34. Ronde | 01.05.2022 | UD SS Reyes | - | Real Valladolid B | 1:1 |  |
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| 35. Ronde | 07.05.2022 | Real Valladolid B | - | CD Badajoz | 1:0 |
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