| 5. Ronde | 18.10.2020 | Tottenham Hotspur | - | West Ham United | 3:3 |  |
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| 7. Ronde | 31.10.2020 | Liverpool FC | - | West Ham United | 2:1 | ||||
| 8. Ronde | 07.11.2020 | West Ham United | - | Fulham FC | 1:0 | ||||
| 9. Ronde | 22.11.2020 | Sheffield United | - | West Ham United | 0:1 | ||||
| 11. Ronde | 05.12.2020 | West Ham United | - | Manchester United | 1:3 | ||||
| 13. Ronde | 16.12.2020 | West Ham United | - | Crystal Palace | 1:1 | ||||
| 15. Ronde | 27.12.2020 | West Ham United | - | Brighton & Hove Albion | 2:2 | ||||
| 16. Ronde | 29.12.2020 | Southampton FC | - | West Ham United | 0:0 | ||||
| 17. Ronde | 01.01.2021 | Everton FC | - | West Ham United | 0:1 | ||||
| 19. Ronde | 16.01.2021 | West Ham United | - | Burnley FC | 1:0 | ||||
| 18. Ronde | 19.01.2021 | West Ham United | - | West Bromwich Albion | 2:1 | ||||
| 24. Ronde | 15.02.2021 | West Ham United | - | Sheffield United | 3:0 | ||||
| 28. Ronde | 14.03.2021 | Manchester United | - | West Ham United | 1:0 | ||||
| 32. Ronde | 17.04.2021 | Newcastle United | - | West Ham United | 3:2 | ||||
| 33. Ronde | 24.04.2021 | West Ham United | - | Chelsea FC | 0:1 | ||||
| 34. Ronde | 03.05.2021 | Burnley FC | - | West Ham United | 1:2 | ||||
| 35. Ronde | 09.05.2021 | West Ham United | - | Everton FC | 0:1 |
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