| 1. Ronde | 07.08.2021 | SC Cham | - | FC Sion II | 2:1 |  |
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| 3. Ronde | 21.08.2021 | SC Cham | - | FC Zürich II | 3:0 | ||||
| 4. Ronde | 28.08.2021 | FC Breitenrain Bern | - | SC Cham | 1:1 | ||||
| 5. Ronde | 04.09.2021 | SC Cham | - | SC Brühl | 0:1 | ||||
| 8. Ronde | 25.09.2021 | SC Cham | - | FC Black Stars Basel | 2:1 | ||||
| 10. Ronde | 09.10.2021 | SC Cham | - | FC Stade Nyonnais | 1:3 | ||||
| 12. Ronde | 23.10.2021 | SC Cham | - | BSC Young Boys II | 1:3 | ||||
| 13. Ronde | 31.10.2021 | FC Chiasso | - | SC Cham | 3:0 |  |
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| 15. Ronde | 13.11.2021 | FC Basel 1893 II | - | SC Cham | 3:4 | ||||
| 16. Ronde | 20.11.2021 | FC Sion II | - | SC Cham | 3:4 | |
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| 17. Ronde | 27.11.2021 | SC Cham | - | Etoile Carouge FC | 1:0 | ||||
| 19. Ronde | 19.02.2022 | SC Cham | - | FC Breitenrain Bern | 0:0 | ||||
| 20. Ronde | 26.02.2022 | SC Brühl | - | SC Cham | 2:2 | ||||
| 22. Ronde | 12.03.2022 | FC Rapperswil-Jona | - | SC Cham | 1:1 | ||||
| 23. Ronde | 19.03.2022 | FC Black Stars Basel | - | SC Cham | 0:2 | ||||
| 24. Ronde | 26.03.2022 | SC Cham | - | FC Bavois | 1:1 | ||||
| 26. Ronde | 06.04.2022 | SC Cham | - | AC Bellinzona | 1:1 | ||||
| 28. Ronde | 16.04.2022 | SC Cham | - | FC Chiasso | 2:4 | ||||
| 30. Ronde | 30.04.2022 | SC Cham | - | FC Basel 1893 II | 2:3 |
Zwitserland