| 1. Ronde | 18.09.2021 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 4:2 | ||||
| 4. Ronde | 09.10.2021 | Deportivo Guadalajara [] | - | Club León [] | 3:0 | ||||
| 6. Ronde | 23.10.2021 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 3:0 | ||||
| 7. Ronde | 30.10.2021 | CF Monterrey [] | - | Deportivo Guadalajara [] | 1:3 | ||||
| 8. Ronde | 06.11.2021 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 3:0 |  |
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| 9. Ronde | 13.11.2021 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:2 | |
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| 10. Ronde | 20.11.2021 | UANL Tigres [] | - | Deportivo Guadalajara [] | 0:1 |
Mexico