| 1. Ronde | 18.09.2021 | FC Juárez [] | - | Puebla FC [] | 1:0 | ||||
| 2. Ronde | 25.09.2021 | Puebla FC [] | - | Deportivo Toluca [] | 2:1 |  |
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| 3. Ronde | 02.10.2021 | CF Pachuca [] | - | Puebla FC [] | 4:0 | ||||
| 4. Ronde | 09.10.2021 | Club Tijuana [] | - | Puebla FC [] | 5:0 | ||||
| 5. Ronde | 16.10.2021 | Puebla FC [] | - | Gallos Blancos [] | 0:1 | ||||
| 7. Ronde | 30.10.2021 | Puebla FC [] | - | FC Juárez [] | 2:1 | ||||
| 8. Ronde | 06.11.2021 | Cruz Azul [] | - | Puebla FC [] | 2:2 | ||||
| 9. Ronde | 13.11.2021 | CF América [] | - | Puebla FC [] | 6:1 | |
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| 10. Ronde | 20.11.2021 | Puebla FC [] | - | Pumas UNAM [] | 2:4 |
Mexico