| 1. Ronde | 25.06.2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 2. Ronde | 02.07.2022 | Club Tijuana [] | - | Santos Laguna [] | 2:0 | ||||
| 3. Ronde | 09.07.2022 | Santos Laguna [] | - | CF Monterrey [] | 3:5 |  |
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| 4. Ronde | 16.07.2022 | Atlético San Luis [] | - | Santos Laguna [] | 2:7 | |
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| 5. Ronde | 23.07.2022 | Santos Laguna [] | - | Mazatlán FC [] | 5:0 | |
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| 7. Ronde | 06.08.2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 2:2 | ||||
| 8. Ronde | 13.08.2022 | Santos Laguna [] | - | UANL Tigres [] | 2:2 | ||||
| 10. Ronde | 28.08.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 1:1 | ||||
| 11. Ronde | 03.09.2022 | Santos Laguna [] | - | Club León [] | 2:0 | |
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| 12. Ronde | 10.09.2022 | UANL Tigres [] | - | Santos Laguna [] | 0:2 | |
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| 13. Ronde | 17.09.2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 2:0 | |
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| 9. Ronde | 21.09.2022 | Club León [] | - | Santos Laguna [] | 4:1 | ||||
| 15. Ronde | 01.10.2022 | Mazatlán FC [] | - | Santos Laguna [] | 2:3 | |
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| 16. Ronde | 08.10.2022 | Santos Laguna [] | - | Atlético San Luis [] | 4:0 | |
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| 17. Ronde | 15.10.2022 | CF Monterrey [] | - | Santos Laguna [] | 1:1 | ||||
| 18. Ronde | 22.10.2022 | Santos Laguna [] | - | Club Tijuana [] | 1:0 | |
Mexico