| 21. Ronde | 27.02.2022 | FK Borec | - | FC Struga | 0:1 | ||||
| 22. Ronde | 09.03.2022 | FC Struga | - | Makedonija GP | 1:3 | ||||
| 23. Ronde | 13.03.2022 | FK AP Brera Strumica | - | FC Struga | 1:0 | ||||
| 24. Ronde | 18.03.2022 | FC Struga | - | KF Shkupi | 1:3 |  |
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| 25. Ronde | 02.04.2022 | FK Rabotnički | - | FC Struga | 1:3 |  |
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| 26. Ronde | 06.04.2022 | GFK Tikvesh | - | FC Struga | 2:0 | ||||
| 27. Ronde | 10.04.2022 | FC Struga | - | FK Skopje | 1:0 | ||||
| 28. Ronde | 16.04.2022 | FK Borec | - | FC Struga | 2:0 | |
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| 29. Ronde | 23.04.2022 | FC Struga | - | FK Pelister | 4:0 | |
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| 30. Ronde | 01.05.2022 | FK Renova | - | FC Struga | 1:1 | ||||
| 31. Ronde | 04.05.2022 | FC Struga | - | FK Bregalnica Štip | 1:0 | |
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| 32. Ronde | 08.05.2022 | Makedonija GP | - | FC Struga | 1:3 |
Gambia