| 1. Ronde | 08.01.2022 | Mazatlán FC [] | - | Atlas Guadalajara [] | 0:4 | ||||
| 2. Ronde | 16.01.2022 | Atlético San Luis [] | - | Mazatlán FC [] | 2:1 | ||||
| 8. Ronde | 26.02.2022 | Mazatlán FC [] | - | Santos Laguna [] | 0:3 | ||||
| 9. Ronde | 05.03.2022 | Club León [] | - | Mazatlán FC [] | 1:1 | ||||
| 10. Ronde | 12.03.2022 | Mazatlán FC [] | - | CF Monterrey [] | 1:3 | ||||
| 11. Ronde | 19.03.2022 | UANL Tigres [] | - | Mazatlán FC [] | 5:0 | ||||
| 12. Ronde | 26.03.2022 | Santos Laguna [] | - | Mazatlán FC [] | 3:2 |  |
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| 13. Ronde | 02.04.2022 | Mazatlán FC [] | - | Club León [] | 0:3 | ||||
| 14. Ronde | 09.04.2022 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 1:2 |  |
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| 15. Ronde | 16.04.2022 | Atlas Guadalajara [] | - | Mazatlán FC [] | 5:1 | |
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| 16. Ronde | 23.04.2022 | Mazatlán FC [] | - | Atlético San Luis [] | 2:0 | ||||
| 17. Ronde | 30.04.2022 | Club Tijuana [] | - | Mazatlán FC [] | 4:0 |
Mexico