| 1. Ronde | 15.05.2021 | Montevideo Wanderers | - | Boston River | 1:0 | ||||
| 2. Ronde | 22.05.2021 | Boston River | - | Rentistas | 1:2 |  |
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| 3. Ronde | 30.05.2021 | Peñarol | - | Boston River | 5:2 | |
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| 4. Ronde | 06.06.2021 | Boston River | - | Montevideo City Torque | 1:2 |  |
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| 5. Ronde | 14.06.2021 | Villa Española | - | Boston River | 2:2 | |
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| 6. Ronde | 19.06.2021 | Boston River | - | Nacional | 1:1 | ||||
| 7. Ronde | 23.06.2021 | Cerrito | - | Boston River | 1:0 | ||||
| 8. Ronde | 27.06.2021 | Boston River | - | Liverpool | 1:1 | ||||
| 9. Ronde | 03.07.2021 | River Plate | - | Boston River | 1:1 | |
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| 10. Ronde | 11.07.2021 | Boston River | - | Cerro Largo | 1:0 | ||||
| 11. Ronde | 16.07.2021 | Progreso | - | Boston River | 1:0 |
Uruguay
Italië