| 2. Ronde | 16.01.2022 | Club Tijuana [U20] | - | Club León [U20] | 1:2 | ||||
| 3. Ronde | 21.01.2022 | Puebla FC [U20] | - | Club Tijuana [U20] | 0:2 | ||||
| 4. Ronde | 06.02.2022 | Club Tijuana [U20] | - | Pumas UNAM [U20] | 1:1 | ||||
| 5. Ronde | 11.02.2022 | Mazatlán FC [U20] | - | Club Tijuana [U20] | 0:2 | ||||
| 12. Ronde | 03.04.2022 | UANL Tigres [U20] | - | Club Tijuana [U20] | 1:2 | ||||
| 9. Ronde | 06.04.2022 | Club Tijuana [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 13. Ronde | 11.04.2022 | CF Pachuca [U20] | - | Club Tijuana [U20] | 0:0 | ||||
| 17. Ronde | 30.04.2022 | CF Monterrey [U20] | - | Club Tijuana [U20] | 3:0 |  |
Mexico