| 1. Ronde | 17.02.2022 | Cobreloa | - | San Luis | 2:1 | ||||
| 6. Ronde | 23.03.2022 | CD Magallanes | - | Cobreloa | 2:1 | ||||
| 9. Ronde | 17.04.2022 | Deportes Iquique | - | Cobreloa | 2:0 | ||||
| 10. Ronde | 21.04.2022 | Cobreloa | - | Barnechea | 3:2 | ||||
| 11. Ronde | 24.04.2022 | Cobreloa | - | Recoleta | 3:0 | ||||
| 14. Ronde | 13.05.2022 | Cobreloa | - | Santiago Wanderers | 1:1 |  |
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| 15. Ronde | 18.05.2022 | Deportes Temuco | - | Cobreloa | 2:0 | ||||
| 16. Ronde | 22.05.2022 | Cobreloa | - | Fernández Vial | 1:0 | |
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| 17. Ronde | 28.05.2022 | Santiago Morning | - | Cobreloa | 0:1 | ||||
| 5. Ronde | 02.06.2022 | Cobreloa | - | Santa Cruz | 1:0 | ||||
| 18. Ronde | 05.07.2022 | San Luis | - | Cobreloa | 0:0 | ||||
| 19. Ronde | 12.07.2022 | Cobreloa | - | Universidad de Concepción | 1:0 | ||||
| 20. Ronde | 19.07.2022 | Deportes Copiapó | - | Cobreloa | 2:0 |
Argentinië