| 21. Ronde | 29.01.2022 | Celta de Vigo B | - | Athletic Club B | 4:1 | ||||
| 22. Ronde | 06.02.2022 | UD Logroñés | - | Athletic Club B | 1:0 | ||||
| 23. Ronde | 12.02.2022 | Athletic Club B | - | Zamora CF | 1:0 |  |
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| 24. Ronde | 20.02.2022 | Rayo Majadahonda | - | Athletic Club B | 1:1 | ||||
| 25. Ronde | 25.02.2022 | Athletic Club B | - | Real Valladolid B | 3:0 | ||||
| 26. Ronde | 06.03.2022 | Unionistas CF | - | Athletic Club B | 0:1 | ||||
| 27. Ronde | 13.03.2022 | Athletic Club B | - | Inter de Madrid | 1:0 | ||||
| 28. Ronde | 20.03.2022 | CF Talavera | - | Athletic Club B | 4:0 | ||||
| 29. Ronde | 27.03.2022 | Athletic Club B | - | CD Tudelano | 1:0 | ||||
| 31. Ronde | 10.04.2022 | Athletic Club B | - | Deportivo La Coruña | 1:1 | ||||
| 32. Ronde | 16.04.2022 | Real Unión | - | Athletic Club B | 1:1 | ||||
| 33. Ronde | 24.04.2022 | Athletic Club B | - | SD Logroñés | 1:0 | ||||
| 34. Ronde | 30.04.2022 | CD Badajoz | - | Athletic Club B | 1:0 | ||||
| 35. Ronde | 08.05.2022 | Athletic Club B | - | CD Calahorra | 1:3 | ||||
| 36. Ronde | 15.05.2022 | Racing Ferrol | - | Athletic Club B | 1:1 | |
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| 37. Ronde | 21.05.2022 | Athletic Club B | - | Racing Santander | 2:1 | ||||
| 38. Ronde | 27.05.2022 | UD SS Reyes | - | Athletic Club B | 2:0 |
Spanje