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| U | Goiás - GO | - | Fluminense RJ | 2:4 (2:4) | ||
| R | Fluminense RJ | - | Goiás - GO | 5:1 (3:0) | ||
| U: 04.05.2022 20:00 | R: 11.05.2022 20:00 | Winnaars: Fluminense RJ | ||||
| U | Bahia - BA | - | Londrina - PR | 3:0 (2:0) | ||
| R | Londrina - PR | - | Bahia - BA | 2:1 (1:0) | ||
| U: 04.05.2022 20:00 | R: 11.05.2022 20:00 | Winnaars: Bahia - BA | ||||
| U | Criciúma - SC | - | Fortaleza | 2:0 (0:0) | ||
| R | Fortaleza | - | Criciúma - SC | 4:0 (1:0) | ||
| U: 04.05.2022 20:00 | R: 11.05.2022 20:00 | Winnaars: Fortaleza | ||||
| U | Palmeiras | - | Remo - PA | 7:0 (1:0) | ||
| R | Remo - PA | - | Palmeiras | 1:4 (0:0) | ||
| U: 04.05.2022 20:00 | R: 12.05.2022 01:00 | Winnaars: Palmeiras | ||||
| U | Cruzeiro | - | Athletico Paranaense | 2:1 (1:0) | ||
| R | Athletico Paranaense | - | Cruzeiro | 2:2 (2:0) | ||
| U: 04.05.2022 20:00 | R: 11.05.2022 20:00 | Winnaars: Cruzeiro | ||||
| U | Atlético Mineiro | - | Cuiabá - MT | 4:1 (3:0) | ||
| R | Cuiabá - MT | - | Atlético Mineiro | 2:9 (2:5) | ||
| U: 04.05.2022 21:00 | R: 11.05.2022 21:00 | Winnaars: Atlético Mineiro | ||||
| U | Vasco da Gama | - | Internacional | 4:0 (2:0) | ||
| R | Internacional | - | Vasco da Gama | 1:3 (1:1) | ||
| U: 05.05.2022 20:30 | R: 09.05.2022 20:30 | Winnaars: Vasco da Gama | ||||
| U | Corinthians SP | - | Sport Recife - PE | 1:1 (1:1) | ||
| R | Sport Recife - PE | - | Corinthians SP | 1:0 (1:0) | ||
| U: 06.05.2022 00:00 | R: 10.05.2022 20:15 | Winnaars: Sport Recife - PE | ||||
