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| U | Gallos Blancos | - | D.C. United | 2:0 (0:0) | ||
| R | D.C. United | - | Gallos Blancos | 1:1 (0:1) | ||
| U: 24.02.2016 02:00 | R: 02.03.2016 02:00 | Winnaars: Gallos Blancos | ||||
| U | Seattle Sounders | - | CF América | 2:2 (1:1) | ||
| R | CF América | - | Seattle Sounders | 3:1 (2:1) | ||
| U: 24.02.2016 04:00 | R: 03.03.2016 02:00 | Winnaars: CF América | ||||
| U | UANL Tigres | - | Real Salt Lake | 2:0 (0:0) | ||
| R | Real Salt Lake | - | UANL Tigres | 1:1 (1:0) | ||
| U: 25.02.2016 02:00 | R: 03.03.2016 04:00 | Winnaars: UANL Tigres | ||||
| U | Los Angeles Galaxy | - | Santos Laguna | 0:0 (0:0) | ||
| R | Santos Laguna | - | Los Angeles Galaxy | 4:0 (3:0) | ||
| U: 25.02.2016 04:00 | R: 02.03.2016 04:00 | Winnaars: Santos Laguna | ||||
