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| U | Deportivo Saprissa | - | UANL Tigres | 1:0 (0:0) | ||
| R | UANL Tigres | - | Deportivo Saprissa | 5:1 (4:1) | ||
| U: 20.02.2019 02:00 | R: 27.02.2019 04:00 | Winnaars: UANL Tigres | ||||
| U | Independiente de La Chorrera | - | Toronto FC | 4:0 (1:0) | ||
| R | Toronto FC | - | Independiente de La Chorrera | 1:1 (1:0) | ||
| U: 20.02.2019 02:00 | R: 27.02.2019 02:00 | Winnaars: Independiente de La Chorrera | ||||
| U | Deportivo Guastatoya | - | Houston Dynamo | 0:1 (0:0) | ||
| R | Houston Dynamo | - | Deportivo Guastatoya | 2:1 (0:0) | ||
| U: 20.02.2019 04:00 | R: 27.02.2019 03:30 | Winnaars: Houston Dynamo | ||||
| U | Marathón | - | Santos Laguna | 2:6 (0:3) | ||
| R | Santos Laguna | - | Marathón | 5:0 (3:0) | ||
| U: 21.02.2019 02:00 | R: 28.02.2019 02:00 | Winnaars: Santos Laguna | ||||
| U | CD Pantoja | - | New York RB | 0:2 (0:1) | ||
| R | New York RB | - | CD Pantoja | 3:0 (2:0) | ||
| U: 21.02.2019 02:00 | R: 28.02.2019 02:00 | Winnaars: New York RB | ||||
| U | Alianza | - | CF Monterrey | 0:0 (0:0) | ||
| R | CF Monterrey | - | Alianza | 1:0 (0:0) | ||
| U: 21.02.2019 04:00 | R: 28.02.2019 04:00 | Winnaars: CF Monterrey | ||||
| U | Sporting Kansas City | - | Deportivo Toluca | 3:0 (1:0) | ||
| R | Deportivo Toluca | - | Sporting Kansas City | 0:2 (0:1) | ||
| U: 22.02.2019 02:00 | R: 01.03.2019 04:00 | Winnaars: Sporting Kansas City | ||||
| U | CS Herediano | - | Atlanta United FC | 3:1 (2:1) | ||
| R | Atlanta United FC | - | CS Herediano | 4:0 (2:0) | ||
| U: 22.02.2019 04:00 | R: 01.03.2019 02:00 | Winnaars: Atlanta United FC | ||||
