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| U | Quilmes | - | Colo-Colo | 0:0 (0:0) | ||
| R | Colo-Colo | - | Quilmes | 2:2 (2:1) | ||
| U: 02.02.2005 00:00 | R: 09.02.2005 00:30 | Winnaars: Quilmes | ||||
| U | Mineros de Guayana | - | América de Cali | 0:2 (0:2) | ||
| R | América de Cali | - | Mineros de Guayana | 3:1 (2:1) | ||
| U: 02.02.2005 02:30 | R: 09.02.2005 02:00 | Winnaars: América de Cali | ||||
| U | Tacuary | - | Palmeiras | 2:2 (1:1) | ||
| R | Palmeiras | - | Tacuary | 2:0 (1:0) | ||
| U: 02.02.2005 22:30 | R: 10.02.2005 00:30 | Winnaars: Palmeiras | ||||
| U | Deportivo Guadalajara | - | Cienciano | 3:1 (1:1) | ||
| R | Cienciano | - | Deportivo Guadalajara | 1:5 (0:0) | ||
| U: 03.02.2005 01:30 | R: 10.02.2005 01:00 | Winnaars: Deportivo Guadalajara | ||||
| U | Atlético Junior | - | Oriente Petrolero | 2:1 (2:0) | ||
| R | Oriente Petrolero | - | Atlético Junior | 1:3 (1:2) | ||
| U: 03.02.2005 22:00 | R: 10.02.2005 23:00 | Winnaars: Atlético Junior | ||||
| U | LDU Quito | - | Peñarol | 3:0 (0:0) | ||
| R | Peñarol | - | LDU Quito | 4:1 (2:1) | ||
| U: 04.02.2005 00:30 | R: 10.02.2005 20:30 | Winnaars: LDU Quito | ||||
