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| U | Lanús | - | Atlas Guadalajara | 0:1 (0:1) | ||
| R | Atlas Guadalajara | - | Lanús | 2:2 (1:0) | ||
| U: 30.04.2008 01:10 | R: 07.05.2008 04:30 | Winnaars: Atlas Guadalajara | ||||
| U | LDU Quito | - | Estudiantes | 2:0 (0:0) | ||
| R | Estudiantes | - | LDU Quito | 2:1 (0:1) | ||
| U: 30.04.2008 03:30 | R: 07.05.2008 02:00 | Winnaars: LDU Quito | ||||
| U | Boca Juniors | - | Cruzeiro | 2:1 (1:0) | ||
| R | Cruzeiro | - | Boca Juniors | 1:2 (0:2) | ||
| U: 30.04.2008 22:40 | R: 08.05.2008 00:10 | Winnaars: Boca Juniors | ||||
| U | San Lorenzo | - | River Plate | 2:1 (1:1) | ||
| R | River Plate | - | San Lorenzo | 2:2 (1:0) | ||
| U: 01.05.2008 00:45 | R: 09.05.2008 01:30 | Winnaars: San Lorenzo | ||||
| U | CF América | - | Flamengo RJ | 2:4 (1:1) | ||
| R | Flamengo RJ | - | CF América | 0:3 (0:2) | ||
| U: 01.05.2008 00:45 | R: 08.05.2008 02:50 | Winnaars: CF América | ||||
| U | Atlético Nacional | - | Fluminense RJ | 1:2 (0:1) | ||
| R | Fluminense RJ | - | Atlético Nacional | 1:0 (0:0) | ||
| U: 01.05.2008 03:00 | R: 06.05.2008 23:30 | Winnaars: Fluminense RJ | ||||
| U | Nacional | - | São Paulo FC | 0:0 (0:0) | ||
| R | São Paulo FC | - | Nacional | 2:0 (1:0) | ||
| U: 01.05.2008 03:00 | R: 08.05.2008 02:50 | Winnaars: São Paulo FC | ||||
| U | Santos FC | - | Cúcuta Deportivo | 2:0 (1:0) | ||
| R | Cúcuta Deportivo | - | Santos FC | 0:2 (0:1) | ||
| U: 02.05.2008 01:45 | R: 09.05.2008 04:15 | Winnaars: Santos FC | ||||
