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| U | Peñarol | - | Universidad Católica | 2:0 (1:0) | ||
| R | Universidad Católica | - | Peñarol | 2:1 (1:0) | ||
| U: 12.05.2011 00:30 | R: 20.05.2011 01:00 | Winnaars: Peñarol | ||||
| U | Once Caldas | - | Santos FC | 0:1 (0:1) | ||
| R | Santos FC | - | Once Caldas | 1:1 (1:1) | ||
| U: 12.05.2011 02:50 | R: 19.05.2011 03:00 | Winnaars: Santos FC | ||||
| U | Vélez Sarsfield | - | Libertad | 3:0 (1:0) | ||
| R | Libertad | - | Vélez Sarsfield | 2:4 (1:1) | ||
| U: 13.05.2011 01:15 | R: 19.05.2011 00:30 | Winnaars: Vélez Sarsfield | ||||
| U | Jaguares Chiapas | - | Cerro Porteño | 1:1 (0:0) | ||
| R | Cerro Porteño | - | Jaguares Chiapas | 1:0 (0:0) | ||
| U: 13.05.2011 03:45 | R: 20.05.2011 03:30 | Winnaars: Cerro Porteño | ||||
