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| U | América - MG | - | Barcelona | 0:0 (0:0) | ||
| R | Barcelona | - | América - MG | 4:5 (0:0, 0:0) d.p. | ||
| U: 09.03.2022 01:30 | R: 16.03.2022 01:30 | Winnaars: América - MG | ||||
| U | Everton | - | Estudiantes | 0:1 (0:0) | ||
| R | Estudiantes | - | Everton | 1:0 (1:0) | ||
| U: 09.03.2022 23:15 | R: 16.03.2022 23:15 | Winnaars: Estudiantes | ||||
| U | Fluminense RJ | - | Club Olimpia | 3:1 (1:1) | ||
| R | Club Olimpia | - | Fluminense RJ | 2:0 (1:0) d.p. | ||
| U: 10.03.2022 01:30 | R: 17.03.2022 01:30 | Winnaars: Club Olimpia | ||||
| U | Universidad Catolica | - | The Strongest | 0:0 (0:0) | ||
| R | The Strongest | - | Universidad Catolica | 2:1 (1:1) | ||
| U: 11.03.2022 01:30 | R: 18.03.2022 01:30 | Winnaars: The Strongest | ||||
