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| U | Lleida Esportiu | - | Barakaldo CF | 1:0 (1:0) | ||
| R | Barakaldo CF | - | Lleida Esportiu | 1:1 (0:0) | ||
| U: 21.05.2016 18:30 | R: 29.05.2016 20:00 | Winnaars: Lleida Esportiu | ||||
| U | Sevilla Atlético | - | UD Socuéllamos | 1:1 (1:1) | ||
| R | UD Socuéllamos | - | Sevilla Atlético | 1:2 (0:0) | ||
| U: 21.05.2016 19:00 | R: 29.05.2016 17:15 | Winnaars: Sevilla Atlético | ||||
| U | Cádiz CF | - | Racing Ferrol | 0:0 (0:0) | ||
| R | Racing Ferrol | - | Cádiz CF | 1:2 (0:2) | ||
| U: 21.05.2016 21:00 | R: 29.05.2016 17:00 | Winnaars: Cádiz CF | ||||
| U | CD Toledo | - | Real Murcia | 0:0 (0:0) | ||
| R | Real Murcia | - | CD Toledo | 1:2 (0:1) | ||
| U: 22.05.2016 17:30 | R: 29.05.2016 18:00 | Winnaars: CD Toledo | ||||
| U | CD Tudelano | - | Hércules CF | 0:1 (0:0) | ||
| R | Hércules CF | - | CD Tudelano | 1:0 (1:0) | ||
| U: 22.05.2016 18:00 | R: 29.05.2016 19:30 | Winnaars: Hércules CF | ||||
| U | UD Logroñés | - | Villarreal CF B | 0:0 (0:0) | ||
| R | Villarreal CF B | - | UD Logroñés | 1:1 (1:1) | ||
| U: 22.05.2016 18:30 | R: 28.05.2016 18:00 | Winnaars: UD Logroñés | ||||
