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| 02.10.2022 | 11:00 | Sevilla Atlético | - | Atlético Sanluqueño CF | 2:3 (0:2) | |
| 12:00 | Utrera CD | - | Recreativo Granada | 3:1 (1:0) | ||
| 12:00 | FC Cartagena B | - | CD El Ejido 2012 | 1:0 (0:0) | ||
| 12:00 | Atlético Mancha Real | - | UCAM Murcia CF | 0:0 (0:0) | ||
| 12:00 | Mar Menor CF | - | Antequera CF | 0:2 (0:1) | ||
| 16:45 | Juventud Torremolinos | - | Yeclano Deportivo | 0:0 (0:0) | ||
| 18:00 | Vélez CF | - | CD San Roque | 0:2 (0:1) | ||
| 18:00 | Xerez DFC | - | Real Betis B | 1:1 (0:0) | ||
| 18:30 | Recreativo Huelva | - | Cádiz CF B | 1:1 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Antequera CF | 5 | 4 | 1 | 0 | 10:3 | 7 | 13 |
| 2 |
|
Mar Menor CF | 5 | 4 | 0 | 1 | 7:4 | 3 | 12 |
| 3 |
|
Real Betis B | 5 | 3 | 1 | 1 | 7:4 | 3 | 10 |
| 4 |
|
Vélez CF | 5 | 2 | 2 | 1 | 7:5 | 2 | 8 |
| 5 |
|
Atlético Sanluqueño CF | 5 | 2 | 2 | 1 | 6:5 | 1 | 8 |
| 6 |
|
Atlético Mancha Real | 5 | 2 | 2 | 1 | 4:3 | 1 | 8 |
| 7 |
|
Recreativo Huelva | 5 | 2 | 2 | 1 | 7:7 | 0 | 8 |
| 8 |
|
CD San Roque | 5 | 2 | 1 | 2 | 6:5 | 1 | 7 |
| 9 |
|
Juventud Torremolinos | 5 | 1 | 4 | 0 | 5:4 | 1 | 7 |
| 10 |
|
Recreativo Granada | 5 | 1 | 3 | 1 | 6:7 | -1 | 6 |
| 11 |
|
UCAM Murcia CF | 5 | 1 | 2 | 2 | 5:5 | 0 | 5 |
| 12 |
|
Yeclano Deportivo | 5 | 1 | 2 | 2 | 3:6 | -3 | 5 |
| 13 |
|
Cádiz CF B | 5 | 1 | 2 | 2 | 6:7 | -1 | 5 |
| 14 |
|
Utrera CD | 5 | 1 | 1 | 3 | 6:8 | -2 | 4 |
| 15 |
|
CD El Ejido 2012 | 5 | 1 | 1 | 3 | 3:6 | -3 | 4 |
| 16 |
|
FC Cartagena B | 5 | 1 | 1 | 3 | 2:5 | -3 | 4 |
| 17 |
|
Xerez DFC | 5 | 0 | 3 | 2 | 2:6 | -4 | 3 |
| 18 |
|
Sevilla Atlético | 5 | 1 | 0 | 4 | 6:8 | -2 | 3 |
| Promotie | |
| Play-offs | |
| Degradatie |
