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| 24.09.2022 | 16:00 | Cruz Azul | - | Puebla FC | 2:1 (0:0) | |
| 16:00 | UANL Tigres | - | Atlético San Luis | 0:0 (0:0) | ||
| 16:00 | Deportivo Toluca | - | FC Juárez | 3:0 (1:0) | ||
| 16:00 | Atlas Guadalajara | - | Mazatlán FC | 3:0 (2:0) | ||
| 16:00 | Gallos Blancos | - | CF América | 1:1 (1:0) | ||
| 16:00 | Club León | - | CF Monterrey | 2:5 (2:1) | ||
| 16:00 | Club Necaxa | - | CF Pachuca | 1:5 (1:4) | ||
| 25.09.2022 | 16:00 | Deportivo Guadalajara | - | Club Tijuana | 4:1 (2:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 12 | 6 | 4 | 2 | 25:17 | 8 | 22 |
| 2 |
|
Club Necaxa | 12 | 6 | 3 | 3 | 30:18 | 12 | 21 |
| 3 |
|
Deportivo Toluca | 12 | 6 | 2 | 4 | 31:24 | 7 | 20 |
| 4 |
|
Cruz Azul | 13 | 5 | 4 | 4 | 28:22 | 6 | 19 |
| 5 |
|
Pumas UNAM | 12 | 5 | 3 | 4 | 15:16 | -1 | 18 |
| 6 |
|
Gallos Blancos | 13 | 5 | 2 | 6 | 16:24 | -8 | 17 |
| 7 |
|
CF Pachuca | 13 | 5 | 1 | 7 | 19:22 | -3 | 16 |
| 8 |
|
FC Juárez | 13 | 3 | 5 | 5 | 18:23 | -5 | 14 |
| 9 |
|
Puebla FC | 12 | 2 | 2 | 8 | 16:32 | -16 | 8 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 13 | 9 | 3 | 1 | 27:13 | 14 | 30 |
| 2 |
|
CF Monterrey | 12 | 8 | 1 | 3 | 30:13 | 17 | 25 |
| 3 |
|
Santos Laguna | 12 | 8 | 1 | 3 | 20:11 | 9 | 25 |
| 4 |
|
Mazatlán FC | 13 | 7 | 1 | 5 | 18:19 | -1 | 22 |
| 5 |
|
Atlas Guadalajara | 12 | 5 | 2 | 5 | 16:14 | 2 | 17 |
| 6 |
|
Atlético San Luis | 13 | 4 | 3 | 6 | 21:24 | -3 | 15 |
| 7 |
|
UANL Tigres | 12 | 4 | 1 | 7 | 11:16 | -5 | 13 |
| 8 |
|
Club Tijuana | 12 | 3 | 2 | 7 | 11:21 | -10 | 11 |
| 9 |
|
Club León | 13 | 0 | 2 | 11 | 17:40 | -23 | 2 |
| Play-offs | |
| Play-offs |
