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| 06.05.2022 | 20:00 | Almere City FC | - | Jong AZ Alkmaar | 0:3 (0:0) | |
| 20:00 | SBV Excelsior | - | NAC Breda | 2:2 (1:1) | ||
| 20:00 | FC Emmen | - | ADO Den Haag | 3:0 (0:0) | ||
| 20:00 | TOP Oss | - | MVV Maastricht | 0:1 (0:1) | ||
| 20:00 | FC Volendam | - | FC Eindhoven | 2:2 (0:1) | ||
| 20:00 | Helmond Sport | - | FC Den Bosch | 1:1 (0:1) | ||
| 20:00 | Jong Ajax | - | De Graafschap | 1:1 (0:0) | ||
| 20:00 | Jong FC Utrecht | - | VVV-Venlo | 2:3 (1:2) | ||
| 20:00 | Jong PSV | - | FC Dordrecht | 1:1 (1:0) | ||
| 20:00 | Roda JC Kerkrade | - | Telstar | 4:3 (1:2) |
| » Stand | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Emmen | 38 | 26 | 5 | 7 | 64:24 | 40 | 83 |
| 2 |
|
FC Volendam | 38 | 21 | 12 | 5 | 81:53 | 28 | 75 |
| 3 |
|
FC Eindhoven | 38 | 21 | 8 | 9 | 69:43 | 26 | 71 |
| 4 |
|
ADO Den Haag | 38 | 22 | 7 | 9 | 76:53 | 23 | 67 |
| 5 |
|
Roda JC Kerkrade | 38 | 18 | 12 | 8 | 77:50 | 27 | 66 |
| 6 |
|
SBV Excelsior | 38 | 19 | 9 | 10 | 82:57 | 25 | 66 |
| 7 |
|
Jong Ajax | 38 | 18 | 9 | 11 | 82:63 | 19 | 63 |
| 8 |
|
NAC Breda | 38 | 16 | 11 | 11 | 60:45 | 15 | 59 |
| 9 |
|
De Graafschap | 38 | 15 | 11 | 12 | 52:43 | 9 | 56 |
| 10 |
|
VVV-Venlo | 38 | 14 | 6 | 18 | 50:64 | -14 | 48 |
| 11 |
|
FC Den Bosch | 38 | 14 | 5 | 19 | 42:61 | -19 | 47 |
| 12 |
|
Jong PSV | 38 | 11 | 11 | 16 | 61:63 | -2 | 44 |
| 13 |
|
Jong AZ Alkmaar | 38 | 12 | 6 | 20 | 39:50 | -11 | 42 |
| 14 |
|
Almere City FC | 38 | 11 | 8 | 19 | 57:69 | -12 | 41 |
| 15 |
|
TOP Oss | 38 | 11 | 8 | 19 | 48:62 | -14 | 41 |
| 16 |
|
MVV Maastricht | 38 | 12 | 4 | 22 | 43:75 | -32 | 40 |
| 17 |
|
FC Dordrecht | 38 | 10 | 9 | 19 | 53:77 | -24 | 39 |
| 18 |
|
Jong FC Utrecht | 38 | 11 | 5 | 22 | 43:67 | -24 | 38 |
| 19 |
|
Telstar | 38 | 8 | 11 | 19 | 47:74 | -27 | 35 |
| 20 |
|
Helmond Sport | 38 | 8 | 7 | 23 | 39:72 | -33 | 28 |
| Promotie | |
| Play-offs | |
| Play-offs |
