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| 28.10.2000 | 20:00 | BV Emmen | - | Go Ahead Eagles | 2:0 (1:0) | |
| 20:00 | Dordrecht '90 | - | FC Den Bosch | 1:3 (0:1) | ||
| 20:00 | SBV Eindhoven | - | Telstar | 0:0 (0:0) | ||
| 20:00 | Heracles Almelo | - | MVV Maastricht | 1:0 (1:0) | ||
| 20:00 | SC Cambuur | - | FC Volendam | 1:0 (1:0) | ||
| 20:00 | HFC Haarlem | - | SBV Excelsior | 2:2 (1:0) | ||
| 20:00 | Helmond Sport | - | ADO Den Haag | 5:0 (1:0) | ||
| 20:00 | FC Zwolle | - | VVV | 1:1 (1:0) | ||
| 20:00 | TOP Oss | - | BV Veendam | 1:2 (0:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 10 | 7 | 1 | 2 | 30:15 | 15 | 22 |
| 2 |
|
FC Den Bosch | 10 | 7 | 0 | 3 | 16:7 | 9 | 21 |
| 3 |
|
Telstar | 10 | 6 | 3 | 1 | 17:13 | 4 | 21 |
| 4 |
|
Go Ahead Eagles | 10 | 6 | 1 | 3 | 20:16 | 4 | 19 |
| 5 |
|
BV Emmen | 10 | 5 | 1 | 4 | 17:10 | 7 | 16 |
| 6 |
|
Heracles Almelo | 10 | 5 | 1 | 4 | 12:11 | 1 | 16 |
| 7 |
|
FC Zwolle | 10 | 4 | 3 | 3 | 17:12 | 5 | 15 |
| 8 |
|
Helmond Sport | 10 | 4 | 2 | 4 | 21:14 | 7 | 14 |
| 9 |
|
FC Volendam | 10 | 4 | 2 | 4 | 11:12 | -1 | 14 |
| 10 |
|
SC Cambuur | 10 | 3 | 4 | 3 | 14:14 | 0 | 13 |
| 11 |
|
BV Veendam | 10 | 4 | 1 | 5 | 16:21 | -5 | 13 |
| 12 |
|
Dordrecht '90 | 10 | 3 | 3 | 4 | 15:19 | -4 | 12 |
| 13 |
|
MVV Maastricht | 10 | 3 | 2 | 5 | 10:15 | -5 | 11 |
| 14 |
|
VVV | 10 | 3 | 1 | 6 | 11:13 | -2 | 10 |
| 15 |
|
SBV Eindhoven | 10 | 2 | 4 | 4 | 14:20 | -6 | 10 |
|
TOP Oss | 10 | 3 | 1 | 6 | 14:20 | -6 | 10 | |
| 17 |
|
ADO Den Haag | 10 | 2 | 2 | 6 | 15:25 | -10 | 8 |
| 18 |
|
HFC Haarlem | 10 | 1 | 4 | 5 | 9:22 | -13 | 7 |
